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Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essentialthrombocythemia myelofibrosis in the Chinese population

Xin Du,Daobin Zhou

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 437-443 doi: 10.1007/s11684-016-0472-9

Abstract: study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 ChineseMF patients.Ruxolitinib treatment was generally well tolerated by Chinese patients.provided substantial reductions in splenomegaly and improvements in symptoms, and was well-tolerated by Chinesepatients with MF.

Keywords： JAK     ruxolitinib     Chinese patients     myelofibrosis    

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Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 773-783 doi: 10.1007/s11684-021-0902-1

Abstract: The total number of cancer patients who are eligible for and will benefit from immune checkpoint inhibitorsThis cross-sectional study was conducted to estimate the number of Chinese cancer patients with eligibilityand response to ICIs based on the 2015 Chinese cancer statistics and the immune checkpoint inhibitorclinical practice guideline of the Chinese Society of Clinical Oncology.In conclusion, ICIs provide considerable benefit in Chinese cancer patients under optimal estimation.

Keywords： benefit     China     eligibility     immune checkpoint inhibitor     public health    

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Outcomes of patients awaiting lung transplantation after the implementation of donation after brain deathat a single Chinese center

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 760-765 doi: 10.1007/s11684-021-0899-5

Abstract: To elaborate the outcomes of patients awaiting lung transplantation (LTx) after the implementation ofA total of 180 patients were enrolled in the study. The median waiting time was 1.25 months.The mortality of patients with ILD (34/103, 33.00%) was nearly twice that of patients with COPD (10/56In the died-waiting group, patients with ILD had a shorter median waiting time than patients with COPDHence, LTx is more urgently needed in patients with ILD and pulmonary hypertension.

Keywords： lung transplantation     donation after brain death     waitlist    

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Predication of increased plasma homocysteine level on the prognosis of Chinese patients with first-onset

YAN Jiangtao, SHAO Jiaomei, WANG Daowen, YUE Zhengliang, HUI Rutai

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 352-355 doi: 10.1007/s11684-008-0067-1

Abstract: was aimed to investigate the relationship between tHcy level and prognosis of first-onset stroke in ChineseOne hundred ninety six patients with first-onset ischemic stroke and ninety-five patients with first-onsetThe patients were divided into two groups in terms of tHcy level (< 18 ?mol/L and ≥ 18 ?mol/L).All the patients underwent a 5-year follow-up.ischemic stroke, but not in hemorrhagic stroke patients.
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Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 736-744 doi: 10.1007/s11684-021-0870-5

Abstract: Traditional Chinese medicine (TCM) presents a favorable prospect in the treatment of pneumoconiosis.A double-blind, randomized, and placebo-controlled trial was conducted for 24 weeks, in which 96 patientsOnly 83 patients from the 96 patients with pneumoconiosis finished the study.differentiation and treatment had a favorable impact on the exercise endurance and quality of life of patients

Keywords： pneumoconiosis     randomized controlled trials     traditional Chinese medicine    

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Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke

Jiangtao YAN, Rutai HUI, Daowen WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 30-35 doi: 10.1007/s11684-009-0005-x

Abstract: hypothesized that elevated levels of hsCRP were associated with worsening prognosis after stroke in Chinesepatients.Furthermore, in the group of patients with stroke, the mean plasma hsCRP level was higher in patientsfindings indicate that increased hsCRP level is associated with worsening prognosis after stroke in Chinesepatients and suggests that inflammation is correlated with stroke outcome.

Keywords： C-reactive protein     inflammation     stroke    

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Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary

Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 255-263 doi: 10.1007/s11684-012-0227-1

Abstract: ursodeoxycholic acid (UDCA) on long-term outcome of primary biliary cirrhosis (PBC) has been less documented in ChineseWe aimed to assess the therapeutic effect of UDCA on Chinese patients with PBC.In the present study, 67 patients with PBC were treated with UDCA (13–15 mg?kg-1?Histological feature was stable in patients at stages 1–2 but still progressed in patients at stagesThe biochemical response of patients at stage 2 was much better than that of patients at stages 3&ndash

Keywords： primary biliary cirrhosis     ursodeoxycholic acid     Chinese     biochemical response     therapeutic efficacy    

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An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patientstreated with traditional Chinese medicine

Jian Wang,Biyan Liang,Xiaoping Zhang,Liran Xu,Xin Deng,Xiuhui Li,Lu Fang,Xinghua Tan,Yuxiang Mao,Guoliang Zhang,Yuguang Wang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 362-367 doi: 10.1007/s11684-014-0363-x

Abstract:

This study aimed to evaluate the therapeutic effect of traditional Chinese medicine (TCM) by observingInformation of 110 HIV/AIDS patients from 19 provinces and cities treated with TCM from 2004 to 2013Long-term use of TCM could maintain or slow the pace of declining CD4 counts in patients with HIV/AIDS

Keywords： AIDS     HIV     CD4     traditional Chinese medicine     linear models    

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Identification of surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential

Fei Liu, Li Liu, Fang Zheng, Xiangdong Tang, Yongxin Bao, Yunxia Zuo

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 189-195 doi: 10.1007/s11684-017-0533-8

Abstract: This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a highResults indicated that only 11.4% of the patients were considered at a high risk of OSAS.Furthermore, the incidence of adverse respiratory events in the PACU was higher in patients with highThe BQ may be adopted as a screening tool for anesthesiologists in China to identify patients who are

Keywords： obstructive sleep apnea     Berlin Questionnaire     Chinese surgical patients     adverse respiratory event    

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Effects of comprehensive therapy based on traditional Chinese medicine patterns on older patients with

Minghang Wang,Jiansheng Li,Suyun Li,Yang Xie

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 368-375 doi: 10.1007/s11684-014-0360-0

Abstract:

This study aimed to evaluate the efficacy of comprehensive therapy based on traditional Chinese medicine(TCM) patterns on older patients with chronic obstructive pulmonary disease (COPD) through a four-centerPatients were divided into the trial group treated using conventional western medicine and Bu-Fei Jian-PiA total of 136 patients≥65 years completed the study, with 63 patients comprising the trial group

Keywords： chronic obstructive pulmonary disease     older adult     clinical trial     Bu-Fei Jian-Pi granules     Bu-Fei Yi-Shen granules     Yi-Qi Zi-Shen granules    

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The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortalityof patients with hepatitis B-related liver failure based on real-world clinical data

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 495-505 doi: 10.1007/s11684-020-0790-9

Abstract: clinical data, the study aimed to explore the effect and mechanisms of the treatment plan of “traditional ChineseA total of 457 patients with HBV-related liver failure were retrospectively collected.The patients were divided into three groups: the modern medicine control group (MMC group), patientstreated with routine medical treatment; the control group combining traditional Chinese and Western medicine(CTW), patients treated with routine medical treatment plus the common TCM formula; and the treatment

Keywords： hepatitis B virus-related liver failure     traditional Chinese medicine     liver regeneration     liver regeneration    

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Mutation analysis of KCNQ1, KCNH2, SCN5A, KCNE1 and KCNE2 genes in Chinese patients with long QT syndrome

DU Rong, TIAN Li, YUAN Guohui, LI Jin, REN Faxin, GUI Le, LI Wei, ZHANG Shouyan, KANG Cailian, YANG Junguo

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 312-315 doi: 10.1007/s11684-007-0060-0

Abstract: The LQTS-causing mutations have been reported in patients and families from Europe, North America andinvestigates the molecular pathology in four families with LQTS (including a family with JLNS) in the ChineseIn this JLNS family, another heterozygous novel mutation in exon 2a was found in of the patients.the identification of polymorphisms and mutations related to LQTS and the Brugada Syndrome (BS) in Chinese

Keywords： recessive Jervell     LQTS-causing     population     autosomal dominant     syndrome    

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CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinesepatients

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 285-294 doi: 10.1007/s11684-021-0843-8

Abstract: CBM.CD19 CAR, a second-generation anti-CD19 CAR bearing 4-1BB costimulatory molecule, for the treatment of patientsTen heavily treated patients with refractory DLBCL were given CBM.CD19 CAR-T cell (C-CAR011) treatmentTreatment-emergent adverse events occurred in all patients.Therefore, C-CAR011 is a safe and effective therapeutic option for Chinese patients with refractory DLBCL

Keywords： CAR-T cell therapy     refractory diffuse large B-cell lymphoma     cytokine release syndrome     dose-limiting toxicity    

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The role played by traditional Chinese medicine in preventing and treating COVID-19 in China

Qingwei Li, Han Wang, Xiuyang Li, Yujiao Zheng, Yu Wei, Pei Zhang, Qiyou Ding, Jiaran Lin, Shuang Tang, Yikun Zhao, Linhua Zhao, Xiaolin Tong

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 681-688 doi: 10.1007/s11684-020-0801-x

Abstract: Traditional Chinese medicine (TCM), an ancient system of alternative medicine, played an active roleIt improved the clinical symptoms of patients, reduced the mortality rate, improved the recovery rateWuchang pattern, mobile cabin hospitals, integrated treatment of TCM and modern medicine for critical patients, and non-medicine therapy for convalescent patients, and describe how TCM effectively treated patients

Keywords： traditional Chinese medicine     COVID-19     Wuchang pattern     mobile cabin hospital     convalescent patients     three    

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A comprehensive information database (CID) of breast cancer patients in China

Shuai Li, Li Fu

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 212-216 doi: 10.1007/s11684-012-0185-7

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Title Author Date Type Operation

Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essentialthrombocythemia myelofibrosis in the Chinese population

Xin Du,Daobin Zhou

Journal Article

Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors

Journal Article

Outcomes of patients awaiting lung transplantation after the implementation of donation after brain deathat a single Chinese center

Journal Article

Predication of increased plasma homocysteine level on the prognosis of Chinese patients with first-onset

YAN Jiangtao, SHAO Jiaomei, WANG Daowen, YUE Zhengliang, HUI Rutai

Journal Article

Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients

Journal Article

Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke

Jiangtao YAN, Rutai HUI, Daowen WANG

Journal Article

Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary

Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan

Journal Article

An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patientstreated with traditional Chinese medicine

Jian Wang,Biyan Liang,Xiaoping Zhang,Liran Xu,Xin Deng,Xiuhui Li,Lu Fang,Xinghua Tan,Yuxiang Mao,Guoliang Zhang,Yuguang Wang

Journal Article

Identification of surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential

Fei Liu, Li Liu, Fang Zheng, Xiangdong Tang, Yongxin Bao, Yunxia Zuo

Journal Article

Effects of comprehensive therapy based on traditional Chinese medicine patterns on older patients with

Minghang Wang,Jiansheng Li,Suyun Li,Yang Xie

Journal Article

The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortalityof patients with hepatitis B-related liver failure based on real-world clinical data

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

Journal Article

Mutation analysis of KCNQ1, KCNH2, SCN5A, KCNE1 and KCNE2 genes in Chinese patients with long QT syndrome

DU Rong, TIAN Li, YUAN Guohui, LI Jin, REN Faxin, GUI Le, LI Wei, ZHANG Shouyan, KANG Cailian, YANG Junguo

Journal Article

CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinesepatients

Journal Article

The role played by traditional Chinese medicine in preventing and treating COVID-19 in China

Qingwei Li, Han Wang, Xiuyang Li, Yujiao Zheng, Yu Wei, Pei Zhang, Qiyou Ding, Jiaran Lin, Shuang Tang, Yikun Zhao, Linhua Zhao, Xiaolin Tong

Journal Article

A comprehensive information database (CID) of breast cancer patients in China

Shuai Li, Li Fu

Journal Article